Premium
Diarylthiopyrimidines and pyridines: Synthesis and biological activity
Author(s) -
Delia Thomas J.,
Kanaar John B.,
Knefelkamp Elizabeth
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390217
Subject(s) - chemistry , pyridine , pyrimidine , nucleophile , benzene , combinatorial chemistry , organic chemistry , stereochemistry , catalysis
Prior work with diarylethers of pyrimidine, pyridine, and benzene showed encouraging antitumor results. As an extension of that work the synthesis of diarylthio derivatives of pyrimidine and pyridine has been accomplished. The synthetic scheme employed the nucleophilic displacement of chlorines from trichloropyrimidine, 1 , dichloropyrimidines 4 and 6 , and 2,6‐dichloropyridine 8 using the anion of thiophe‐nols 2 . Antitumor evaluation by the National Cancer Institute showed no useful activity.