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On triazoles XLV [1]. synthesis of 5,7‐diamino‐1,2,4‐triazolo[1,5‐ a ] [1,3,5]triazines
Author(s) -
Berecz Gábor,
Pongó László,
Kövesdi István,
Reiter József
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390214
Subject(s) - chemistry , yield (engineering) , crystal structure , medicinal chemistry , computational chemistry , crystallography , thermodynamics , physics
Dedicated to Professor András Messmer on the occasion of his 80 th birthday The reaction of differently substituted 5‐amino‐1,2,4‐triazoles ( 5 ) with isothiourea derivatives ( 3 ) to yield isomeric 5,7‐diamino‐1,2,4‐triazolo[1,5‐ a ][1,3,5]triazines ( 6 and 7 ), previously described as not proceeding in melt, was performed in different solvents as well as in the melt at 150‐160°. It was proved that the above reaction had rather general validity. The structure of isomers 6 and 7 were proved spectroscopically. The structure of 6/5 (Q = ethylamino) was corroborated with single crystal X‐ray diffraction determination, as well.