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Synthesis and reactions of 2‐amino‐6‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐4‐phenylpyridine‐3‐carbonitrile
Author(s) -
Ahmed R. A.,
Kandeel M. M.,
Abbady M. S.,
Youssef M. S. K.
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390211
Subject(s) - chemistry , methyl iodide , triethyl orthoformate , formamide , acetic anhydride , hydrazine (antidepressant) , isothiocyanate , medicinal chemistry , chloride , ethyl iodide , acetic acid , iodide , nitrous acid , phenyl isothiocyanate , carbonylation , organic chemistry , hydroxylamine , acetyl chloride , halide , hydrate , catalysis , carbon monoxide , chromatography
Abstract 2‐Amino‐6‐(3‐methyl‐5‐oxo‐1‐phenyl‐2‐pyrazolin‐4‐yl)‐4‐phenylpyridine‐3‐carbonitrile (1) obtained by the reaction of 4‐(1‐iminoethyl)‐3‐methyl‐1‐phenyl‐2‐pyrazolin‐5‐one with benzylidenemalononitrile, was reacted with triethyl orthoformate followed by hydrazine hydrate, acetic anhydride, acetyl chloride, alkyl halides, benzoyl chloride, sulphuric acid followed by formamide, phenyl isothiocyanate, carbon disulphide followed by ethyl iodide, formamide, trichloroacetonitrile, nitrous acid, giving new oxopyrazolinylpyridines ( 2,3,5,6,8,9,10 ) and related pyridopyrimidines ( 11‐17 ) and pyridotriazine ( 18 ).