New  trans/cis  tetrahydroisoquinolines. 1.  trans ‐2‐benzyl‐3‐(l‐methyl‐1 h ‐pyrrol‐2‐yl)‐4‐substituted‐1,2,3,4‐tetrahydroisoquinolin‐1‐ones and corresponding tetrahydroisoquinolines | Zendy

Kozekov I. D. | Zendy; Koleva R. I. | Zendy; Palamareva M. D. | Zendy

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New trans/cis tetrahydroisoquinolines. 1. trans ‐2‐benzyl‐3‐(l‐methyl‐1 h ‐pyrrol‐2‐yl)‐4‐substituted‐1,2,3,4‐tetrahydroisoquinolin‐1‐ones and corresponding tetrahydroisoquinolines

Author(s) -

Kozekov I. D.,

Koleva R. I.,

Palamareva M. D.

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390134

Subject(s) - chemistry , benzylamine , medicinal chemistry , tetrahydroisoquinoline , benzene , stereochemistry , carboxylic acid , cis–trans isomerism , organic chemistry

The reaction of homophthalic anhydride and N ‐(1‐methyl‐1 H ‐pyrrol‐2‐yl‐methylidene)‐benzylamine in boiling benzene afforded as a main product the expected substituted trans ‐1,2,3,4‐tetrahydroisoquinoline‐4‐carboxylic acid 5 . The carboxylic group of 5 was transformed in four steps into cyclic amino‐methyl groups yielding numerous new tetrahydroisoquinolinones 11a‐j incorporating a given fragment of pharmacological interest. Reduction of 11a‐j was studied.

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