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Reaction of 2,5‐dimethylpyrroles with quinones. Synthesis of new pyrrolylquinones
Author(s) -
Lion Dyes Claude,
Baudry Richard,
Hedayatullah Mir,
Da Conceiçlato Louis,
Genard Sylvie,
Maignan Jean
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390118
Subject(s) - chemistry , naphthoquinone , quinoxaline , quinone , quinoline , 1,4 naphthoquinone , stereochemistry , combinatorial chemistry , medicinal chemistry , organic chemistry
The reaction of 1,4‐naphthoquinone ( 1 ) with 2,5‐dimethylpyrroles ( 7a‐7d ) gives only 3‐(1,4‐naphtho‐quinonyl)‐2,5‐dimethylpyrroles. Extending the reaction to other quinones: 5‐hydroxy‐1,4‐naphthoquinone ( 2 ), 1,2‐naphthoquinone ( 3 ), quinoline‐5,8‐dione ( 4 ) and quinoxaline‐5,8‐dione ( 5 ), of which nothing was known, allows the synthesis of new pyrrolylquinones.