Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl  n ‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (hei 81) by using  n ‐acyl iminium salts methodologies | Zendy

Bourry Anne | Zendy; Pitard Franck | Zendy; Rigo Benoît | Zendy; Sanz Géarard | Zendy; Camus Fabrice | Zendy; Norberg Bernadette | Zendy; Durant Françlois | Zendy; Couturier Daniel | Zendy

Premium

Studies on pyrrolidinones: Some attempts to improve the synthesis of methyl n ‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (hei 81) by using n ‐acyl iminium salts methodologies

Author(s) -

Bourry Anne,

Pitard Franck,

Rigo Benoît,

Sanz Géarard,

Camus Fabrice,

Norberg Bernadette,

Durant Françlois,

Couturier Daniel

Publication year - 2002

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570390116

Subject(s) - chemistry , iminium , pyrrolidinones , oxazole , salt (chemistry) , polymerization , acylation , stereochemistry , organic chemistry , polymer , catalysis

Some ways to use the N ‐acyl iminium salt methodologies to synthesize a new inhibitor of tubulin polymerization, methyl N ‐(3,4,4′,5‐tetramethoxybenzhydryl)pyroglutamate (HEI 81) were studied. The most interesting reactions utilize a new pyroglutamic lactone (3‐(3,4,5‐trimethoxyphenyl)dihydropy‐rrolo[1,2‐ c ]oxazole‐1,5‐dione).

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research