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An improved procedure for the deamination of symmetrical 3,5‐disubstituted 4‐amino‐1,2,4‐triazoles
Author(s) -
Bentiss Fouad,
Lagrenee Michel,
Vezin Hervéa,
Bouanis Marya,
Mernari Bouchaib
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390113
Subject(s) - deamination , chemistry , combinatorial chemistry , oxidative deamination , amino acid , stereochemistry , computational chemistry , organic chemistry , enzyme , biochemistry
A number of symmetrical 3,5‐disubstituted‐4 H ‐1,2,4‐triazoles have been synthesized in good yields by deamination of the corresponding 4‐amino‐1,2,4‐triazoles via reductive diazotation of these amino compounds in the presence of hypophosphorous acid. Analytical, spectral data and theoretical calculations confirmed the structures of the new triazole derivatives.