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Synthesis and spectral properties of 11‐[( o ‐; and p ‐substituted)‐phenyl]‐8‐[( o ‐; m ‐; p ‐methoxy)phenylthio]‐3,3‐dimethyl‐2,3,4,5,10,11‐hexahydro‐1 h ‐dibenzo[ b , e ][1,4]diazepin‐1‐ones
Author(s) -
Cortéas Eduardo Cortéas,
Sanabria Ana María Hernández,
Mellado Olivia García
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390107
Subject(s) - chemistry , benzaldehyde , condensation , spectral properties , medicinal chemistry , stereochemistry , organic chemistry , computational chemistry , physics , thermodynamics , catalysis
The preparation of twelve novel 2,3,4,5,10,11‐hexahydro‐1 H ‐dibenzo[ b , e ] [1,4]diazepin‐l‐ones which have potentially useful pharmacological properties; by condensation and cyclization between 3‐{[4‐( o ‐; m ‐; p ‐methoxy)phenylthio]‐1,2‐phenylenediamine}‐5,5‐dimethyl‐2‐cyclohexenone with ( o ‐; and p ‐substi‐tuted)benzaldehyde. The structure of all final products were corroborated by ir, 1 H‐nmr, 13 C‐nmr and ms.