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A convenient one‐pot synthesis and antimicrobial activity of pyrimido[1,2‐ b ][1,2,4,5]tetrazines
Author(s) -
Shawali Ahmad S.,
Abdallah Magda A.,
Zayed Mohie M.
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390105
Subject(s) - chemistry , antimicrobial , antifungal , halide , pyrimidine , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry , microbiology and biotechnology , biology
The synthesis of the hitherto unreported 3‐amino‐2,3‐dihydro‐6‐phenyl‐2‐thioxo‐4(1 H )‐pyrimidine 2 and 3‐amino‐2‐methylthio‐6‐phenyl‐4(3 H )‐pyrimidinone 3 is described. Reactions of hydrazonoyl halides 1 with either 2 or 3 afforded 6 H ‐pyrimido[1,2‐ b ][1,2,4,5]tetrazin‐6‐ones 6. The latter products were screened for their antifungal and antibacterial properties. The mechanism of the studied reactions is discussed.