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Synthesis of 2‐amino‐1,4‐dihydro‐4‐quinolinones and diaminomethylene meldrum's acids derivatives as potential potassium channel openers
Author(s) -
Erb Béanéadicte,
Rigo Benoît,
Pirotte Bernard,
Couturier Daniel
Publication year - 2002
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570390102
Subject(s) - chemistry , diazoxide , pinacidil , potassium channel opener , meldrum's acid , potassium , amobarbital , potassium channel , benzopyrans , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biophysics , biology , medicine , glibenclamide , neuroscience , insulin , epilepsy , diabetes mellitus , endocrinology
Starting from 5‐bismethylthiomethylene Meldrum's acid, the synthesis of 5‐diaminomethylene Meldrum's acids and 2‐aminoquinolone derivatives, structurally related to potassium channels openers pinacidil and diazoxide, is described.