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Synthesis and characterization of some coumarins with two hydroxy or methoxy substituents
Author(s) -
Fall Yagamare,
Santana Lourdes,
Uriarte Eugenio
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380534
Subject(s) - chemistry , yield (engineering) , hydrolysis , coumarin , methylation , stereochemistry , organic chemistry , medicinal chemistry , biochemistry , materials science , metallurgy , gene
The first synthesis of the 6‐hydroxy‐4‐methoxycoumarin ( 5 ) was carried out in 25 % overall yield from 6‐methoxy‐4‐hydroxycoumarin ( 1 ) by hydrolysis of the methoxy group and subsequent selective methylation of the hydroxyl group at position 4. The 1 H and 13 C NMR data of compounds 1–6 are reported.