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Reactivity of 4‐chlorobenzo[ c ][2,7]naphthyridines towards Pd(0) catalyzed coupling reactions and nucleophilic substitutions. aroylation by nucleophilic substitution with analogues of acyl anions
Author(s) -
Duvey G.,
Nivoliers F.,
Rocca P.,
Godard A.,
Marsais F.,
Quéguiner G.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380505
Subject(s) - chemistry , nucleophilic substitution , reactivity (psychology) , nucleophile , medicinal chemistry , iodide , catalysis , substitution reaction , derivative (finance) , stereochemistry , organic chemistry , medicine , alternative medicine , pathology , financial economics , economics
Various 4‐substituted benzo[ c ][2,7]naphthyridines were prepared from the corresponding 4‐chloro derivative by Pd(0) coupling reaction or nucleophilic substitution. More particularly, 4‐aroyl‐benzo[e][2,7]naph‐thyridines were synthesized by aroylation with arenecarbaldehydes in the presence of 1,3‐dimethylimida‐zolium iodide.
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