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Synthesis of new 5‐substitutedbenzo[ b ]thiophene derivatives
Author(s) -
PérezSilanes S.,
MartínezEsparza J.,
Oficialdegui A. M.,
Villanueva H.,
Orúas L.,
Monge A.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380502
Subject(s) - chemistry , thiophene , aryl , nitro , stereochemistry , propane , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Previous works of our group have dealt with the synthesis of 1‐(aryl)‐3‐[4‐(aryl)piperazin‐1‐yl]propane derivatives in the search for new and efficient antidepressants with a dual mode of action: serotonin reuptake inhibition and 5‐HT 1A receptor afinity [1‐4]. From these studies we concluded that the 3‐[4‐(aryl)piperazin‐1‐yl]‐1‐(benzo[ b ]thiophen‐3‐yl)propane derivatives led to the best results. The continuation of this research project required the preparation of some new 3‐acyl‐5‐substituted benzo[ b ]thiophenes with a wide variety of substituents at the 5 position, ranging from nitro to hydroxyl derivatives. To obtain these derivatives we acylated the corresponding 5‐substituted benzo[ b ]thiophenes when it was possible.