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A library of pyranocoumarin derivatives via a one‐pot three‐component hetero diels‐alder reaction
Author(s) -
Cravotto Giancarlo,
Nano Gian Mario,
Tagliapietra Silvia,
Palmisano Giovanni,
Pilati Tullio
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380425
Subject(s) - chemistry , diels–alder reaction , coumarin , component (thermodynamics) , organic chemistry , combinatorial chemistry , catalysis , physics , thermodynamics
A hetero Diels‐Alder reaction with inverse electron demand between 4‐hydroxycoumarin, aromatic aldehydes and electron‐rich alkenes yielded a multitude of 2,4‐disubstituted 3,4‐dihydropyranocoumarins. This route opened an easy access to coumarin anticoagulants and provided a library of pyranocoumarin derivatives.
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