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Efficient one‐pot synthesis of s‐triazolo[3,4‐ b ]‐[1,3,5]thiadiazines containing a chiral side chain by double mannich type reaction
Author(s) -
Shi Haijian,
Shi Haoxin,
Wang Zhongyi
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380418
Subject(s) - chemistry , mannich reaction , combinatorial chemistry , aryl , reaction conditions , chain (unit) , stereochemistry , organic chemistry , catalysis , alkyl , physics , astronomy
An efficient and convenience method has been developed via a one‐pot double Mannich type reaction for the synthesis of the important chiral s‐triazole derivatives: ( S )‐3‐α‐phenylethyl‐2,4‐dihydro‐5‐aryl‐oxymethyl‐1,2,4‐triazolo [3,4‐ b ] ‐1,3,5 ‐thiadiazines.
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