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Preparation of pyrrolo[2,1,5‐ cd ]indolizine Derivatives by intramolecular condensation of 3‐acyl‐5‐methylindolizines
Author(s) -
Liang Feng,
Hu Jiaxin,
Zhang Lande,
Hu Yuefei,
Hu Hongwen
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380408
Subject(s) - indolizine , chemistry , intramolecular force , condensation , sequence (biology) , combinatorial chemistry , reaction conditions , condensation reaction , organic chemistry , stereochemistry , catalysis , biochemistry , physics , thermodynamics
An efficient two step route has been developed to synthesize pyrrolo[2,1,5‐ cd ]indolizine derivatives. The reaction sequence proceeds via preparation of 3‐acyl‐5‐methylindolizines followed by an intramolecular condensation. The procedures were carried out under convenient conditions and gave the products in high yields. It could be expected to be used to prepare a broad range of potentially interesting pyrrolo[2,1,5‐ cd ]indolizine derivatives.