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Random optimizations for direct heteronuclear correlations
Author(s) -
Hadden Chad E.,
Moon Joe B.,
Hadden Daneen T. A.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380406
Subject(s) - heteronuclear molecule , chemistry , signal (programming language) , coherence (philosophical gambling strategy) , apodization , algorithm , range (aeronautics) , pulse sequence , computational physics , statistics , optics , nuclear magnetic resonance , physics , computer science , stereochemistry , nuclear magnetic resonance spectroscopy , mathematics , materials science , composite material , programming language
A novel optimization method is described for the acquisition of direct one‐bond heteronuclear correlations. The RDSQC (Randomly optimized Direct correlation Single Quantum Coherence) experiment utilizes an optimization based on the randomly ordered sampling of a range of couplings. The random order of the l/(2*( 1 J CHmin )) delays removes the signal dependency on a single type of apodization, thus eliminating a significant portion of the F 1 artifacts induced in the accordion‐optimized ADSQC experiment. Compared to the statically optimized GHSQC, the randomly optimized data maintains the desired signal intensity in most cases, with a small loss for the weakly coupled proton‐carbon pairs and significant gains for the more strongly coupled pairs. Compared to the accordion‐optimized ADSQC data, the randomly optimized data afforded similar signal‐to‐noise without the F 1 modulated artifacts simplifying spectral interpretation.