Premium
A facile synthesis of fluorine‐containing heterocycles ‐ use of 1,1,1‐trifluoro‐2‐alkanones as a convenient synthetic intermediate
Author(s) -
Kamitori Yasuhiro
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380339
Subject(s) - chemistry , aldehyde , ammonia , fluorine , organic chemistry , aqueous solution , combinatorial chemistry , catalysis
1,1,1‐Trifluoro‐2,3‐alkanediones 2 easily obtainable from various aldehyde dialkylhydrazones were reacted with several diamines to afford trifluoromethylquinoxalines 3 and trifluoromethylpyrazines 4 in good yields. With the use of aldehydes and aqueous ammonia instead of diamines, diketones 2 were successfully converted to the corresponding 4‐trifluoromethylimidazoles 5 in satisfactory yields.