Premium
Synthesis of dihydrolysergol analogues
Author(s) -
Mantegani Sergio,
Traquandi Gabriella,
Varasi Mario
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380336
Subject(s) - chemistry , indole test , benzoxazole , ring (chemistry) , quinoline , chirality (physics) , quinazoline , stereochemistry , combinatorial chemistry , biological activity , axial chirality , organic chemistry , enantioselective synthesis , catalysis , biochemistry , in vitro , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark
As a part of a search for novel biological active ergoline derivatives, the indole ring present in the ergoline skeleton (indole[4,3‐ f,g ]quinoline) was converted into different heterocyclic ring systems such as quinazoline 2 , benzofurane 3 and benzoxazole 4 . Due to the paramount importance of chirality to attain biological activity, natural dihydrolysergic acid 1 was chosen as starting material and a synthetic pathway conservative in term of chirality was followed.