Synthesis of dihydrolysergol analogues | Zendy

Mantegani Sergio | Zendy; Traquandi Gabriella | Zendy; Varasi Mario | Zendy

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Synthesis of dihydrolysergol analogues

Author(s) -

Mantegani Sergio,

Traquandi Gabriella,

Varasi Mario

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380336

Subject(s) - chemistry , indole test , benzoxazole , ring (chemistry) , quinoline , chirality (physics) , quinazoline , stereochemistry , combinatorial chemistry , biological activity , axial chirality , organic chemistry , enantioselective synthesis , catalysis , biochemistry , in vitro , chiral symmetry breaking , physics , quantum mechanics , nambu–jona lasinio model , quark

As a part of a search for novel biological active ergoline derivatives, the indole ring present in the ergoline skeleton (indole[4,3‐ f,g ]quinoline) was converted into different heterocyclic ring systems such as quinazoline 2 , benzofurane 3 and benzoxazole 4 . Due to the paramount importance of chirality to attain biological activity, natural dihydrolysergic acid 1 was chosen as starting material and a synthetic pathway conservative in term of chirality was followed.

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