Synthesis and biological study of 6‐polyhydroxyalkylpteridines | Zendy

López M. Dolores | Zendy; Quijano M. Luisa | Zendy; Sánchez Adolfo | Zendy; Nogueras Manuel | Zendy; Low John N. | Zendy

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Synthesis and biological study of 6‐polyhydroxyalkylpteridines

Author(s) -

López M. Dolores,

Quijano M. Luisa,

Sánchez Adolfo,

Nogueras Manuel,

Low John N.

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380331

Subject(s) - chemistry , condensation , combinatorial chemistry , stereochemistry , organic chemistry , physics , thermodynamics

6‐Polyhydroxyalkylpteridines are synthesised by oxidation of the corresponding pyrano[3,2‐ g ]pteridines, the latter ones having been obtained by condensation between 5,6‐diaminopyrimidines 1a,b and phenylhydra‐zones 2a‐e . The relative configuration at the chiral centers of the pyrano[3,2‐ g ]pteridines has been determined by nmr study and X‐ray analysis. The anti‐AIDS activity of several of these compounds has been tested.

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