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Synthesis and biological study of 6‐polyhydroxyalkylpteridines
Author(s) -
López M. Dolores,
Quijano M. Luisa,
Sánchez Adolfo,
Nogueras Manuel,
Low John N.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380331
Subject(s) - chemistry , condensation , combinatorial chemistry , stereochemistry , organic chemistry , physics , thermodynamics
6‐Polyhydroxyalkylpteridines are synthesised by oxidation of the corresponding pyrano[3,2‐ g ]pteridines, the latter ones having been obtained by condensation between 5,6‐diaminopyrimidines 1a,b and phenylhydra‐zones 2a‐e . The relative configuration at the chiral centers of the pyrano[3,2‐ g ]pteridines has been determined by nmr study and X‐ray analysis. The anti‐AIDS activity of several of these compounds has been tested.