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Preparation of substituted 1,2‐Dihydro‐3 H ‐pyrazol‐3‐ones from polylithiated 2′‐phenylphenylacetohydrazides and aromatic esters
Author(s) -
Downs Jennifer R.,
Pastine Stefan J.,
Townsend Jessica D.,
Greer Heather A.,
Kelley Wayne,
Schady Deborah A.,
Mcconaughy Teresa Lentz,
Metz Clyde R.,
Beam Charles F.,
Almquist Catharine D.,
Pennington William T.,
Walsch Rosa D. Bailey
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380326
Subject(s) - lithium diisopropylamide , chemistry , lithium (medication) , organic chemistry , medicinal chemistry , ion , deprotonation , medicine , endocrinology
Several 2′‐phenylphenylacetohydrazides were polylithiated with excess lithium diisopropylamide, and the resulting intermediates were condensed with several aromatic esters to afford C ‐acylated intermediates that were not usually isolated, but acid cyclized directly to 1,4,5‐trisubstituted, 1,2‐dihydro‐3 H ‐pyrazol‐3‐ones.