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Preparation of 1 H ‐pyrazole‐5‐carboxamides from dilithiated C(α), N ‐phenylhydrazones and lithiated ethyl oxanilates or lithiated ethyl oxamate
Author(s) -
Downs Jennifer R.,
Pastine Stefan J.,
Schady Deborah A.,
Greer Heather A.,
Kelley Wayne,
Embree Mildred C.,
Townsend Jessica D.,
Beam Charles F.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380325
Subject(s) - chemistry , lithium diisopropylamide , pyrazole , ethyl ester , lithium (medication) , medicinal chemistry , organic chemistry , ion , deprotonation , endocrinology , medicine
Dilithiated C(α), N ‐phenylhydrazones were prepared in excess lithium diisopropylamide and condensed with either ethyl oxanilate, ethyl 4′‐chlorooxanilate, or ethyl oxamate to give intermediates that were quenched and acid cyclized to substituted l H ‐pyrazole‐5‐carboxamides.