Preparation of 1 H ‐pyrazole‐5‐carboxamides from dilithiated C(α),  N ‐phenylhydrazones and lithiated ethyl oxanilates or lithiated ethyl oxamate | Zendy

Downs Jennifer R. | Zendy; Pastine Stefan J. | Zendy; Schady Deborah A. | Zendy; Greer Heather A. | Zendy; Kelley Wayne | Zendy; Embree Mildred C. | Zendy; Townsend Jessica D. | Zendy; Beam Charles F. | Zendy

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Preparation of 1 H ‐pyrazole‐5‐carboxamides from dilithiated C(α), N ‐phenylhydrazones and lithiated ethyl oxanilates or lithiated ethyl oxamate

Author(s) -

Downs Jennifer R.,

Pastine Stefan J.,

Schady Deborah A.,

Greer Heather A.,

Kelley Wayne,

Embree Mildred C.,

Townsend Jessica D.,

Beam Charles F.

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380325

Subject(s) - chemistry , lithium diisopropylamide , pyrazole , ethyl ester , lithium (medication) , medicinal chemistry , organic chemistry , ion , deprotonation , endocrinology , medicine

Dilithiated C(α), N ‐phenylhydrazones were prepared in excess lithium diisopropylamide and condensed with either ethyl oxanilate, ethyl 4′‐chlorooxanilate, or ethyl oxamate to give intermediates that were quenched and acid cyclized to substituted l H ‐pyrazole‐5‐carboxamides.

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