A versatile synthesis of 4,5‐dihydropyrrolo[1,2‐a]quinoxalines | Zendy

Abonia Rodrigo | Zendy; Insuasty Braulio | Zendy; Quiroga Jairo | Zendy; Kolshorn Heinz | Zendy; Meier Herbert | Zendy

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A versatile synthesis of 4,5‐dihydropyrrolo[1,2‐a]quinoxalines

Author(s) -

Abonia Rodrigo,

Insuasty Braulio,

Quiroga Jairo,

Kolshorn Heinz,

Meier Herbert

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380321

Subject(s) - chemistry , acetic acid , pyrrole , catalysis , organic chemistry , quinoxaline , ethanol , medicinal chemistry , combinatorial chemistry

The reaction of 1‐(2‐aminophenyl)pyrrole with aromatic or heteroaromatic aldehydes in ethanol and catalytic amounts of acetic acid leads to 4,5‐dihydropyrrolo[1,2‐ a ]quinoxalines in high yields. When aliphatic aldehydes were used under the same conditions, a slow oxidation to the corresponding pyrrolo[1,2‐ a ]quinoxalines can occur; the oxidation can be avoided by preparing in situ the 5‐acetyl derivatives of the 4,5‐dihydropyrrolo[1,2‐ a ]quinoxalines.

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