Synthesis of 3‐Carboxylic derivatives of 1,5‐benzodiazepines | Zendy

Mansour O. | Zendy; Szymonski B. | Zendy; Morand J. M. | Zendy; Cussac M. | Zendy; Thomasson F. | Zendy

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Synthesis of 3‐Carboxylic derivatives of 1,5‐benzodiazepines

Author(s) -

Mansour O.,

Szymonski B.,

Morand J. M.,

Cussac M.,

Thomasson F.

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380315

Subject(s) - chemistry , dibenzoylmethane , diethyl malonate , malonate , moiety , derivative (finance) , halogenation , malonic acid , medicinal chemistry , carboxylic acid , organic chemistry , catalysis , financial economics , economics

A series of 3‐carboxylic derivatives of disubstituted 1,5‐benzodiazepines (5–9) was synthesized by hetero‐cyclisation from 1,2‐diaminobenzene (1) with dibenzoylmethane (2) followed by bromination on position 3 and by introduction of the carboxylic group or introduction of the malonic moiety. Reduction of the hetero‐cycle gave the perhydro derivative diethyl (2,4‐diphenyl‐1,2,4,5‐tetrahydro‐3 H ‐1,5‐benzodiazepin‐3‐yl)malonate (9) .

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