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Synthesis of 2(3H)‐benzoxazolone and 2(3H)‐benzothiazolone derivatives as potential beta‐3‐adrenergic receptor ligands (part 2)
Author(s) -
Delhomel J. F.,
Yous S.,
Depreux P.,
Lesieur D.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380314
Subject(s) - chemistry , adrenergic receptor , beta (programming language) , lipolysis , adrenergic , receptor , stereochemistry , b2 receptor , beta 3 adrenergic receptor , pharmacology , combinatorial chemistry , biochemistry , medicine , adipose tissue , computer science , programming language , bradykinin
Adrenoceptors beta‐3‐subtype mediate lipolysis and in the search for potential beta‐3‐adrenergic receptors agonists for the treatment of obesity, we designed new arylethanolamines (structures 4, 5 ) and aryloxypropanolamines (structures 6, 7 ) derived from 2(3 H )‐benzoxazolone and 2(3 H )‐benzothiazolone.