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Facile synthesis of 3‐substituted [1,2,4]triazino[3,4‐ f ]purine‐4,6,8‐trione derivatives
Author(s) -
Settimo Federico Da,
Marini Anna Maria,
Pardi Gianluca,
Primofiore Giampaolo,
Salerno Silvia,
Simorini Francesca
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380309
Subject(s) - chemistry , glyoxylic acid , purine , condensation , purine analogue , pyrimidine , stereochemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics , enzyme
A new synthetic route to build the [1,2,4]triazino[3,4‐ f ]purine nucleus is described. The novel [1,2,4]‐triazino[3,4‐ f ]purine‐4,6,8(l H ,7 H ,9 H )‐trione derivatives were obtained by condensation of 8‐hydrazinotheophylline with appropriate glyoxylic acids via the intermediate hydrazones.