Premium
Asymmetric borane reduction of ketones promoted by menthopyrazole‐zncl 2 complex
Author(s) -
Kashima Choji,
Tsukamoto Yoshihiro,
Miwa Yohei,
Higashide Kohei
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380308
Subject(s) - chemistry , borane , enantioselective synthesis , zinc , catalysis , reduction (mathematics) , medicinal chemistry , pyrazole , ketone , organic chemistry , chloride , mathematics , geometry
The enantioselective reduction of ketones was accomplished by borane in the presence of pyrazole derivatives, particularly 2‐methoxymethyl‐3‐phenyl‐1‐menthopyrazole (8). The catalysis of zinc chloride makes it possible to lower the reaction temperature below 0 °C, and to promote enantioselectivity.