Premium
Reaction of 3‐substituted and 4‐bromo‐3‐substituted isoquinolin‐1‐(2 h )‐ones with propargyl bromide
Author(s) -
Usifoh Cyril Odianose
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380307
Subject(s) - chemistry , propargyl bromide , potassium carbonate , anhydrous , propargyl , dimethylformamide , bromide , alkylation , medicinal chemistry , organic chemistry , potassium bromide , potassium , catalysis , solvent
Isoquinolinones were brominated using N ‐bromosuccinimide in dimethylformamide at room temperature to give 4‐bromo‐3‐substituted isoquinolin‐1‐(2 H )‐ones. The reaction of these isoquinolinones with propargyl bromide in the presence of anhydrous potassium carbonate yielded N and O ‐alkylated products.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom