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An improved synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ‐ a conformationally‐restricted analog of 2‐(3‐pyridyl)ethylamine
Author(s) -
Dow Robert L.,
Schneider Steven R.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380241
Subject(s) - ethylamine , chemistry , pharmacophore , sequence (biology) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry
The 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ( 7 ) pharmacophore has the potential to serve as a confor‐mationally‐locked analog of the pharmacologically active 2‐(3‐pyridyl)ethylamine ( 1 ) core structure. This paper describes the synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ( 7 ) via a five‐step sequence, which affords a significant improvement over previously reported syntheses.