An improved synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ‐ a conformationally‐restricted analog of 2‐(3‐pyridyl)ethylamine | Zendy

Dow Robert L. | Zendy; Schneider Steven R. | Zendy

Premium

An improved synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ‐ a conformationally‐restricted analog of 2‐(3‐pyridyl)ethylamine

Author(s) -

Dow Robert L.,

Schneider Steven R.

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380241

Subject(s) - ethylamine , chemistry , pharmacophore , sequence (biology) , combinatorial chemistry , stereochemistry , organic chemistry , biochemistry

The 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ( 7 ) pharmacophore has the potential to serve as a confor‐mationally‐locked analog of the pharmacologically active 2‐(3‐pyridyl)ethylamine ( 1 ) core structure. This paper describes the synthesis of 5,6,7,8‐tetrahydro‐1,7‐naphthyridine ( 7 ) via a five‐step sequence, which affords a significant improvement over previously reported syntheses.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research