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Preparation of novel 2‐(benzo[ b ]furan‐2‐yl)‐1 H ‐imidazolines for photoaffinity labelling and affinity isolation of imidazoline binding
Author(s) -
Clews Proteins J.,
Ramsden Christopher A.,
Morgan Noel G.
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380237
Subject(s) - imidazoline receptor , chemistry , labelling , photoaffinity labeling , furan , stereochemistry , receptor , combinatorial chemistry , biochemistry , organic chemistry , pharmacology , medicine
The preparations of 5‐aminoefaroxan 8 and 5‐azidoefaroxan 9 , which retain the capacity to stimulate insulin secretion via the putative I 3 imidazoline receptor and are useful biological tools for affinity chromatography studies and photoaffinity labelling studies of imidazoline binding proteins, are described