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A facile synthesis of some thieno/furo‐[2,3‐ d ]pyrimidine‐2‐yl‐thioacetic acid derivatives
Author(s) -
Demirayak S̨Eref,
Mohsen Usama Abu
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380234
Subject(s) - chemistry , pyrimidine , stereochemistry , combinatorial chemistry , organic chemistry
The reaction of 2‐(α‐chloroacetamido)‐3‐cyano‐4,5‐disubstituted thiophenes/furanes with ammonium thiocyanate in methanol or ethanol afforded methyl or ethyl (4‐amino‐5,6‐disubstituted thieno/furo[2,3‐ d ]‐pyrimidine‐2‐yl)thioacetates in good yields.