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Synthesis of substituted pyrimido[4,5‐ b ] and [5,4‐ c ]‐[1,8]naphthyridines
Author(s) -
Plisson Christophe,
Chenault Jacques
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380225
Subject(s) - chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry
Ethyl 1‐ethyl‐7‐methyl‐4‐oxo‐1,4‐dihydro[1,8]naphthyridine‐3‐carboxylate ( 1 ), precursor of nalidixic acid, has been converted in two steps through ([1,8]naphthyridin‐3‐yl)carbonylguanidine derivatives into substituted pyrimido[4,5‐ b ] and [5,4‐ c ][1,8]naphthyridines.
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