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Synthesis of chiral fused heterocyclic compounds containing 1,2,4‐triazole ring
Author(s) -
Shi Haoxin,
Wang Zhongyi,
Shi Haijian
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380206
Subject(s) - ethylamine , chemistry , ring (chemistry) , aryl , 1,2,4 triazole , triazole , condensation , stereochemistry , medicinal chemistry , organic chemistry , alkyl , physics , thermodynamics
A series of new chiral ( S )‐3‐ary1‐6‐pyrrolidin‐2‐yl‐[1,2,4]triazolo[3,4‐ b ]thiadiazole (II 1‐5 ), ( S )‐1‐(3‐aryl‐[1,2,4]triazolo[3,4‐ b ][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II 6‐8 ) and ( S )‐1,2‐bis(3‐aryl‐[1,2,4]triazolo‐[3,4‐ b ][1,3,4]thiadiazol‐6‐yl)‐ethylamine (II 9‐11 ) were prepared by the condensation of 3‐aryl‐4‐amino‐5‐mercapto‐1,2,4‐triazoles with different L‐amino acids in the presence of phosphorus oxychloride and evaluated for their antibacterial activity.