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Synthesis of a new series of purine derivatives and their anti‐cyclin‐dependent kinase activities
Author(s) -
Legraverend Michel,
Ludwig Odile,
Leclerc Sophie,
Meijer Laurent
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380145
Subject(s) - chemistry , cyclin dependent kinase , substituent , kinase , purine , methanol , purine analogue , stereochemistry , cell cycle , biochemistry , enzyme , cell , organic chemistry
The synthesis of new purine derivatives designed to inhibit cell cycle regulating cyclin‐dependent kinases (CDKs), is reported. These compounds, related to olomoucine and roscovitine, are characterised by the presence of apyrrolidine methanol substituent at C‐2 and a variety of ortho, meta and/or para substituents on the C‐6 arylamino group.