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Facile synthesis of mono and dibenzo N , N '‐disubstituted diaza 18‐crown‐6 derivatives
Author(s) -
Topal Giray,
Demirel Nadir,
Toğrul Mahmut,
Turgut Yilmaz,
Hoşgören Halil
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380142
Subject(s) - chemistry , yield (engineering) , amine gas treating , crown (dentistry) , distillation , organic chemistry , combinatorial chemistry , medicinal chemistry , medicine , materials science , dentistry , metallurgy
This study represents a facile synthesis of building blocks ( 1–3 ) of crown ethers and amine precoursers ( 4a‐d ). The study also involves synthesis of mono and dibenzo N, N ‐disubstituted diaza 18‐crown‐6 derivatives with high yield without chromatographic purification and high vacuum distillation. The complex ability of host the ethers was evaluated in terms of structural modification.