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Transformations of schiff bases derived from quinoline‐8‐carbaldehyde. Synthesis of C‐8 substituted quinolines
Author(s) -
Ocal Nüket,
Yolaçan ÇIgdem,
Kaban ŞEniz,
Leonor Vargas M.,
Kouznetsov Vladimir
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380135
Subject(s) - aldimine , chemistry , quinoline , reagent , bromide , medicinal chemistry , organic chemistry , aryl , catalysis , alkyl
The Schiff bases derived from quinoline‐8‐carbaldehyde and substituted aromatic amines were used in the synthesis of C‐8 substituted quinolines. 3‐Aryl‐2‐(8‐quinolinyl)‐4‐thiazolidinones were prepared from obtained aldimines by means of the cyclocondensation of mercapto acids. A series of 4‐ N ‐arylamino‐4‐(8‐quinolinyl)‐1‐butenes was synthesized through the addition of the Grignard reagent (allylmagnesium bromide) to the double bond C=N of these aldimines. The structure of the prepared compounds was established on the basis of their elemental analyses and spectral data.