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N ‐bromosuccinimide reactions of some heterocycles in the presence or absence of water: An overview of ring versus side chain bromination for the synthesis of important brominated heterocyclic synthons
Author(s) -
Goswami Shyamaprosad,
Ghosh Kumaresh,
Mukherjee Reshmi,
Adak Avijit Kumar,
Mahapatra Ajit Kumar
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380125
Subject(s) - synthon , chemistry , halogenation , n bromosuccinimide , ring (chemistry) , side chain , perchloric acid , reaction conditions , organic chemistry , medicinal chemistry , catalysis , polymer
Reactions of various heterocycles 1–6 with N ‐bromosuccinimide in the presence or absence of water have been studied for side chain versus ring bromination to afford some new and important heterocyclic synthons. Interestingly, the N ‐bromosuccinimide reaction in the presence of perchloric acid, a new condition, affords exclusively the new dibromo aminopicoline 1f , which is not obtained by other presently studied methods.