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Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV‐1 reverse transcriptase inhibitors
Author(s) -
Heinisch Gottfried,
Matuszczak Barbara,
Spielmann Elisabeth,
Witvrouw Myriam,
Pannecouque Christophe,
De Clercq Erik
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380117
Subject(s) - chemistry , reverse transcriptase , human immunodeficiency virus (hiv) , virology , virus , stereochemistry , biochemistry , rna , biology , gene
Abstract Two methods for the preparation of dialkylsubstituted dipyridazino[4,3‐ b :3′,4′‐ e ][1,4]diazepinones and dipyridazino[3,4‐ b :3′,4′‐ e ][1,4]diazepinones are reported. The new compounds were evaluated for their inhibitory effects against the replication of human immunodeficiency virus [HIV‐1(III B ) and HIV‐2(ROD)] in MT‐4 cells.