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Synthesis and reaction of 5,6,7,8‐tetrahydro‐4 H ‐oxazolo[4,5‐c]azepin‐4‐ones
Author(s) -
Koh Young Kook,
Bang KiHwan,
Kim HongSeok
Publication year - 2001
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570380112
Subject(s) - chemistry , ethyl bromoacetate , alkylation , alkyl , stereochemistry , medicinal chemistry , organic chemistry , catalysis
The synthesis of 5,6,7,8‐tetrahydro‐4 H ‐oxazolo[4,5‐ c ]azepin‐4‐ones 5a,b and 1,3‐benzoxazol‐4‐amines 4a,b are described starting from 4,5,6,7‐tetrahydro‐1,3‐benzoxazol‐4‐ones. Thionation of 5a,b followed by alkylation with ethyl bromoacetate led to the corresponding S ‐alkyl azepines 7a,b .
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