Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal | Zendy

Gong Yuefa | Zendy; Kato Katsuya | Zendy; Kimoto Hiroshi | Zendy

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Convenient substitution of hydroxypyridines with trifluoroacetaldehyde ethyl hemiacetal

Author(s) -

Gong Yuefa,

Kato Katsuya,

Kimoto Hiroshi

Publication year - 2001

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570380103

Subject(s) - chemistry , hemiacetal , anhydrous , yield (engineering) , potassium carbonate , organic chemistry , catalysis , medicinal chemistry , metallurgy , materials science

Thermal substitution of 4‐hydroxypyridine 1 with trifluoroacetaldehyde ethyl hemiacetal (TFAE) leads to a moderate yield of 3‐(1‐hydroxy‐2,2,2‐trifluoroethyl)‐4‐hydroxypyridine 7 in the presence of a catalytic amount of anhydrous potassium carbonate. Under similar conditions, several α‐trifluoromethyl hydroxy‐pyridinemethanols 8–15 are easily prepared from 2‐ or 3‐hydroxypyridines 2–6 .

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