An improved synthesis of pyrazolo[3,4‐ b ][1,5]benzoxazepine, ‐benzothiazepine and ‐benzodiazepine derivatives  via  a convenient one‐pot synthesis | Zendy

Abd El Latif Fawi M. | Zendy

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An improved synthesis of pyrazolo[3,4‐ b ][1,5]benzoxazepine, ‐benzothiazepine and ‐benzodiazepine derivatives via a convenient one‐pot synthesis

Author(s) -

Abd El Latif Fawi M.

Publication year - 2000

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570370643

Subject(s) - chemistry , benzodiazepine , combinatorial chemistry , d 1 , stereochemistry , medicinal chemistry , receptor , biochemistry

An improved and simple method for the preparation of pyrazolo[3,4‐ b ][1,5]benzoxazepine, ‐benzothiazepine and ‐benzodiazepine derivatives was established by the reaction of 5‐chloro‐1‐phenylpyrazole‐4‐carbaldehydes, ethyl 3‐(5‐chloro‐1,3‐diphenylpyrazol‐4‐yl)‐2‐cyanoacrylate and 1,4‐diacetyl‐3‐methyl‐2‐pyrazolin‐5‐one with o‐aminophenol derivatives and o‐phenylendiamine.

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