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A facile synthesis of 3 H ‐indolium perchlorates by one‐pot hydrazone formation/fischer indolization
Author(s) -
Zimmermann Thomas
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370626
Subject(s) - chemistry , hydrazone , perchloric acid , boiling , ethanol , organic chemistry , medicinal chemistry
N ‐Substituted N ‐phenylhydrazines 1, α‐branched ketones 2 and perchloric acid react in boiling ethanol to give via the in situ formed hydrazones 3 1,2,3,3‐tetrasubstituted 3 H ‐indolium perchlorates 4. The scope and limitations of this facile synthesis of 3 H ‐indolium derivatives which combines the hydrazone formation and the Fischer indolization to an one‐pot procedure are discussed.