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Further studies on polycyclic arene sulfides. Preparation and mutagenic activity of 9, 10, 10a, 11a‐tetrahydrotriphenyleno[1,2‐ b ]‐thiirene, 1a,2,3,10b‐tetrahydro‐5 H ‐thiereno[3,4]benzo[1,2‐ b ]fluorene and 1a,2,3,11b‐tetrahydroacenaphtho[1′,2′:6,7]naphth[1,2‐ b ]thiirene
Author(s) -
Blum Jochanan,
Kogan Vladimir,
Glatt Hansruedi
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370514
Subject(s) - chemistry , fluoranthene , triphenylene , fluorene , stereochemistry , pyrene , organic chemistry , medicinal chemistry , molecule , polymer
The title compounds 6 , 8 and 10 , which are dihydroarene sulfides of the environmental pollutants triphenylene, benzo[ b ]fluorene and benzo[ k ]fluoranthene, have been synthesized from the corresponding epoxides and N,N ‐dimethylthioformamide. The mutagenicity of the episulfides has been investigated using Salmonella typhimurium strains TA98 and TA100. While compounds 6 and 10 were mutagenic, the tetrahydrobenzo[ b ]fluorene episulfide 8 was inactive.