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A series of diarylsubstituted oximes as potential substrate for new aldose reductase inhibitors
Author(s) -
Rakowitz Dietmar,
Heinisch Gottfried,
Lukavsky Peter,
Kiendler Sigrid,
Trenkwalder Cornelia,
Barlocco Daniela,
Rastelli Giulio,
Costantino Luca
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370511
Subject(s) - chemistry , aldose reductase , ring (chemistry) , stereochemistry , substrate (aquarium) , aldose , in vitro , combinatorial chemistry , enzyme , organic chemistry , biochemistry , glycoside , oceanography , geology
In the course of our research aimed at the discovery of new compounds acting as aldose reductase inhibitors, we tested a series of some ( E )‐ and ( Z )‐ω‐[[(aryldiazinylmethylene)amino]oxy]alkanoic acids, which were found to have moderate in vitro inhibitory activity. On this basis we have now prepared several new derivatives modified both at the length of the chain and at its terminal carboxylic group, together with compounds carrying various substituents at the phenyl ring. This paper describes their synthesis and biological properties.