Premium
New isomeric N ‐substituted hydrazones of 2‐, 3‐ and 4‐pyridinecarboxaldehydes and methyl‐3‐pyridylketone
Author(s) -
Wyrzykiewicz Elzbieta,
Blaszczyk Alfred
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370448
Subject(s) - chemistry , conformational isomerism , fragmentation (computing) , amide , sulfoxide , hydrazone , dimethyl sulfoxide , medicinal chemistry , stereochemistry , molecule , organic chemistry , computer science , operating system
Twelve compounds unknown in the literature N ‐( E )‐2‐stilbenyloxymethylenecarbonyl substituted hydrazones of 2‐, 3‐ and 4‐pyridinecarboxaldehydes, as well as methyl‐3‐pyridylketone have been prepared. The stereochemical behavior of these compounds in dimethyl‐d 6 sulfoxide solution has been studied by 1 H NMR technique. The E geometrical isomers and cis/trans amide conformers have been found for N ‐substituted hydrazones 1–12. EI induced mass spectral fragmentation of these compounds were also investigated. The data obtained create the basis for distinguishing isomers.