Convenient synthesis of 1,2,3,4‐tetrahydro‐pyrimidin‐5‐ylbenzoxazoles | Zendy

Jung Myung Hee | Zendy; Choi SungWon | Zendy; Cho KuiWoong | Zendy

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Convenient synthesis of 1,2,3,4‐tetrahydro‐pyrimidin‐5‐ylbenzoxazoles

Author(s) -

Jung Myung Hee,

Choi SungWon,

Cho KuiWoong

Publication year - 2000

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570370447

Subject(s) - chemistry , iodobenzene , condensation , agonist , combinatorial chemistry , annulation , medicinal chemistry , organic chemistry , catalysis , receptor , biochemistry , physics , thermodynamics

2‐Pyrimidin‐5‐ylbenzoxazoles 7 have been synthesized by condensation of 5‐pyrimidinecarboxaldehyde 4 with substituted aminophenols 5 followed by oxidative cyclization of the resulting Schiff's bases 6 with iodobenzene diacetate. Subsequent formation of methylpyrimidinium salts 8 and reduction thereafter afforded tetrahydropyrimidinylbenzoxazoles 10. This method has been utilized in the synthesis of M 1 muscarinic agonist candidates.

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