Premium
Synthesis of bicyclic azacompounds (3‐dimethylcarbamoyloxyphenyl) substituted as acetylcholinesterase inhibitors
Author(s) -
Borioni Anna,
Giudice Maria Rosaria Del,
Mustazza Carlo,
Gatta Franco
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370422
Subject(s) - chemistry , bicyclic molecule , formamide , acetylcholinesterase , methylamine , ammonium acetate , reductive amination , amination , ammonium , organic chemistry , enzyme , catalysis , high performance liquid chromatography
This paper describes the synthesis of some bicyclic 2‐(3‐dimethylcarbamoyloxyphenyl) substituted azaderivatives, obtained from 1,4‐ and 1,5‐diketones, which were cyclized with ammonium acetate, methylamine and by reductive amination. Corresponding 3‐substituted derivatives were instead prepared by reaction of 1,5‐ketoesters with formamide. The carbamates were tested as in vitro acetylcholinesterase inhibitors.