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An improved procedure for the synthesis of 4,4‐disubstituted‐3‐oxo‐1,2,5‐thiadiazolidine 1,1 ‐dioxides
Author(s) -
Xiao Zejun,
Timberlake Jack W.
Publication year - 2000
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.5570370418
Subject(s) - chemistry , computational chemistry , combinatorial chemistry , medicinal chemistry
An improved synthesis for the preparation of 3‐oxo‐1,2,5‐thiadiazolidine 1,1‐dioxides has been developed. This facile two‐step procedure fromα‐amino acid esters and chlorosulfonyl isocyanate results in excellent yields of products.