Pyrrolo[3,4‐ e ][1,2,3]triazolo[1,5‐ a ]pyrimidine and pyrrolo[3,4‐ d ] [1,2,3]triazolo[1,5‐ a ]pyrimidine. New tricyclic ring systems of biological interest | Zendy

Lauria Antonino | Zendy; Diana Patrizia | Zendy; Barraja Paola | Zendy; Almerico Anna Maria | Zendy; Cirrincione Girolamo | Zendy; Dattolo Gaetano | Zendy

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Pyrrolo[3,4‐ e ][1,2,3]triazolo[1,5‐ a ]pyrimidine and pyrrolo[3,4‐ d ] [1,2,3]triazolo[1,5‐ a ]pyrimidine. New tricyclic ring systems of biological interest

Author(s) -

Lauria Antonino,

Diana Patrizia,

Barraja Paola,

Almerico Anna Maria,

Cirrincione Girolamo,

Dattolo Gaetano

Publication year - 2000

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570370413

Subject(s) - acetonitriles , chemistry , pyrimidine , ring (chemistry) , dimethyl sulfoxide , sulfoxide , stereochemistry , medicinal chemistry , organic chemistry , acetonitrile

Derivatives of the new ring system pyrrolo[3,4‐ e ][1,2,3] triazolo[1,5‐ a ]pyrimidine 6 were prepared in high yields in one step by reaction of 3‐azidopyrrole 3 and substituted acetonitriles. Compound 6b rearranged, upon heating in dimethyl sulfoxide in the presence of water, to pyrrolo[3,4‐ d ][1,2,3]triazolo‐[1,5‐ a ]pyrimidine 7.

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