Reaction of 4,5,6‐triaminopyrimidine and 2,4,5,6‐tetraaminopyrimidine with 3‐dimethylaminopropiophenones. Synthesis of new 4‐aryl‐2,3‐dihydropyrimido[4,5‐ b ][1,4]diazepines | Zendy

Braulio Insuasty O. | Zendy; Henry Insuasty I. | Zendy; Jairo Quiroga P. | Zendy; Saitz Claudio | Zendy; Jullian Carolina | Zendy

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Reaction of 4,5,6‐triaminopyrimidine and 2,4,5,6‐tetraaminopyrimidine with 3‐dimethylaminopropiophenones. Synthesis of new 4‐aryl‐2,3‐dihydropyrimido[4,5‐ b ][1,4]diazepines

Author(s) -

Braulio Insuasty O.,

Henry Insuasty I.,

Jairo Quiroga P.,

Saitz Claudio,

Jullian Carolina

Publication year - 2000

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.5570370228

Subject(s) - chemistry , regioselectivity , aryl , ethanol , medicinal chemistry , computational chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl , catalysis

Several new 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐ b ][1,4]diazepines were obtained from the reaction of 4,5,6‐triaminopyrimidine 1a and 2,4,5,6‐tetraaminopyrimidine 1b with one equivalent of 3‐dimethylaminopropiophenones 2 in absolute ethanol. Structure analysis of 6‐amino‐ and 6,8‐diamino‐4‐aryl‐2,3‐dihydropyrimido[4,5‐ b ][1,4]diazepines 3a‐i , determined by detailed nmr measurements, reveals a high regioselectivity of this reaction.

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